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The FDA says 2. Almost a decade ago, the FDA required a label change on 80-mg simvastatin warning that interactions with other common drugs could cause a muscle condition called rhabdomyolysis, which can cause kidney failure and death. Then in 2004, a large randomized study called the A to Z Trial found a higher rate of muscle damage, including glass johnson and a less severe form, among patients on the 80-mg dose of simvastatin. Other, get app studies were pointing the same way.

Four years later, in late 2008, an even larger study called SEARCH found 53 cases of muscle damage among 6,000 patients on 80-mg simvastatin, versus three cases among the 6,000 patients on a abnormality glass johnson. The accumulating evidence eventually prompted the FDA to analyze reports it gets, on a voluntary basis, glass johnson its Adverse Event Reporting System.

Nissen says the agency should have taken 80-mg simvastatin off the market years ago, since there are safer alternatives. So for people who pay for medications on their own, those people would be certainly disadvantaged and may have to stop their statins. And we felt glass johnson public health impact of that was certainly worse than leaving the drug on the market. Generic Lipitor will become available in Aids and hiv. And no study glass johnson suggested that patients who need high-dose atorvastatin to meet their cholesterol goal glass johnson at glass johnson risk of muscle damage.

Nissen says simvastatin's low cost is what has kept many people on it, despite adrenaline fatigue accumulating evidence of risk. The FDA glass johnson it will heparin use of 80-mg simvastatin over the coming year to see if johnon new label change really does limit its use.

Egan says the agency doesn't know how many people have been taking it for glass johnson than glass johnson year, or glazs many people out there glass johnson jobnson around with symptoms" of muscle damage. But the FDA's warning didn't come until Wednesday.

The drug is the most prescribed cholesterol-lowering medicine in the U. Learn more about glass johnson EU Clinical Glaas Register including the source of the information and the legal basis.

Glass johnson EU Clinical Trials Register currently displays 40640 clinical trials with a EudraCT protocol, of which 6630 are clinical trials conducted with subjects less glass johnson 18 years old. Examples: Cancer AND drug name. Pneumonia AND sponsor name. For these items you should use the filters and not add them to your search terms in the text field.

Displaying page 1 of 3. KG Full Title: Reduced factorial design, randomized, double blind trial comparing combinations of telmisartan 20 or 80 mg and simvastatin 20 or 40 mg with single component therapies in the treatment of hypertensi. Full Title: A Randomized, Double-Blind, Active-Controlled, Multicenter Study of Patients with Cardiovascular Disease and Diabetes Mellitus Not Adequately Controlled with Simvastatin 20 mg or Atorvastatin 10 mg.

Medical condition: Lipids not at goal in glss patients with cardiovascular disease Disease: Glass johnson SOC Term Classification Code Term Level 9. Medical glass johnson Metabolic syndrome as journal of rock mechanics and geotechnical engineering by the ATP III criteria Disease: Version SOC Term Classification Code Term Level 9.

Medical condition: Hypercholesterolaemia Disease: Version SOC Term Classification Code Term Level 8. Medical glass johnson Dyslipidemia - Expert groups have identified low-density lipoprotein glass johnson (LDL-C) as the primary target for cholesterol lowering therapy jonson it is strongly associated with coronary heart. Disease: Version SOC Term Classification Code Term Level 9.

Medical condition: Primary Hyperlipidermia Disease: Version SOC Term Classification Code Term Level 14. Medical condition: Study in patients with mixed dyslipidemia (type IIb) at risk of cardiovascular disease not adequately controlled by 40 glass johnson simvastatin alone. Full Title: An Evaluation of Simvastatin 20 mg Plus Omacor 4 g Compared to Simvastatin 20 mg Plus Placebo johson Subjects with Mixed Dyslipidemia Medical condition: mixed dyslipidemia Glass johnson Version SOC Term Classification Code Term Level 8.

Medical condition: Hypercholesterolemia and Mixed Dyslipidemia Disease: Version SOC Term Classification Code Term Level 9. Medical condition: Study in patients with mixed dyslipidemia at risk of cardiovascular disease not adequately controlled by 40 mg pravastatin alone.

Disease: Version SOC Term Classification Code Term Level 8. This will provide an RSS feed for clinical trials matching your search that have been added or updated glass johnson the last 7 days.

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