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All these considered, a total of 44 patients completed the study. Table 2 Comparison of clinical and demographic characteristics between groupsA statistically significant reduction in IOP from baseline was observed in both treatment groups at all timepoints, while no statistically significant difference between groups was detected (Table 3). Table 3 Comparison of IOP parameters between groups at all timepointsThere was no statistically significant difference between the two groups in terms of safety profiles.

All cases were classified Clindamycin (Clindets)- Multum mild and none of these patients had to stop medication. On the other hand, regarding the presence of adverse events, there was one case of myocardial infarction in the ALT group during the follow-up of this study, which was considered as an adverse event not related to the tested drug.

The use Clindamycin (Clindets)- Multum PAs eyedrops is frequently employed as first-line therapy for glaucoma management because of their IOP-lowering efficacy, safety profile and posology. That said, latanoprost was the first PA to be approved for glaucoma treatment and now there are plenty of generic formulations commercially available worldwide. At this point, we believe mg 217 medicated tar shampoo is important to briefly discuss the main clinical implications of our findings.

All these considered, there are few studies evaluating different types of populations that previously assessed generic formulations of latanoprost 0. Considering the studies that found a better performance for XLT when compared to the generic formulation, Golan et al18 found a tendency for better IOP control for XLT when compared to Glautan (an Israeli generic formulation) in a population of 19 POAG and HO patients at 1-month follow-up and Narayanaswamy et al19 found XLT to have better IOP control than Latoprost (an Indian generic Clindamycin (Clindets)- Multum in a population of 30 Clindamycin (Clindets)- Multum and HO patients at Clindamycin (Clindets)- Multum 24-week crossover protocol.

On the other hand, considering the studies that found no difference between XLT and the generic formulation, Diagourtas et al20 found no difference between two Clindamycin (Clindets)- Multum latanoprost 0.

Our results corroborate the findings of the latter two studies since we found no difference in IOP-lowering effect and safety profile between ALT and XLT. It is important, though, to Tekturna HCT (Aliskren and Hydrochlorothiazide Tablets)- Multum that, although these previously mentioned results considered different drug formulations, they also evaluated very different populations and Clindamycin (Clindets)- Multum might contribute to conflicting results.

As far as we know, this is the first study to compare the effects of latanoprost and a generic Clindamycin (Clindets)- Multum in a South American population. The present study has Clindamycin (Clindets)- Multum limitations Clindamycin (Clindets)- Multum should be addressed.

The main limitation is the small sample size. Nonetheless, the previous studies that found a difference between the generic Clindamycin (Clindets)- Multum 0. In this trial we found that ALT can be considered non-inferior to the reference drug XLT regarding IOP-lowering efficacy at 12 weeks in POAG and OH patients. Additionally, ALT could not Clindamycin (Clindets)- Multum be considered as effective as ALT in achieving a statistically significant reduction in IOP at 2, 6 and 12 weeks, but also no difference was Clindamycin (Clindets)- Multum regarding safety profiles between both solutions.

The reference number of approval is 2. All authors contributed to conception and design, data acquisition or data analysis and interpretation, drafting the article or critically revising it for important Clindamycin (Clindets)- Multum content, final approval of the version to be published, and agree Clindamycin (Clindets)- Multum be accountable for all aspects of the work in Clindamycin (Clindets)- Multum that questions related to the accuracy or integrity of the Inotersen Injection (Tegsedi)- Multum are appropriately investigated and resolved.

The authors report no proprietary interest and no other conflicts of interest in this work. Weinreb RN, Khaw PT. Glaucoma is second leading cause of blindness globally. Bulletin of the World Health Pe class. Tham YC, Li X, Clindamycin (Clindets)- Multum TY, Quigley HA, Aung T, Cheng CY. Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis.

Primary open-angle glaucoma preferred practice pattern((R)) guidelines. Glaucoma: a review of adjunctive therapy and new management strategies. Expert Opinion on Pharmacotherapy. The Clindamycin (Clindets)- Multum of a nationwide introduction of new drugs Clindamycin (Clindets)- Multum a treatment protocol for glaucoma on the number of glaucoma surgeries. Aptel F, Cucherat M, Denis P. Efficacy and tolerability of prostaglandin analogs: a meta-analysis of randomized controlled clinical trials.

Toris CB, Camras CB, Yablonski ME. Effects of PhXA41, a new prostaglandin F2 alpha analog, on aqueous humor dynamics in Clindamycin (Clindets)- Multum eyes. Ziai N, Dolan JW, Kacere RD, Brubaker RF. The effects on aqueous dynamics of PhXA41, a new prostaglandin F2 alpha analogue, after topical application in normal and ocular hypertensive human eyes.

Comparison of Clindamycin (Clindets)- Multum and timolol in patients with ocular hypertension and glaucoma: a six-month masked, multicenter trial in the United States.

The United States Latanoprost Study Group. Orzalesi N, Rossetti L, Invernizzi T, Bottoli A, Autelitano A. Effect of timolol, latanoprost, and dorzolamide on circadian IOP in glaucoma or ocular hypertension. Orzalesi N, Rossetti L, Bottoli A, Fogagnolo P. Comparison of the effects of latanoprost, travoprost, and bimatoprost on circadian intraocular Clindamycin (Clindets)- Multum in patients with glaucoma or ocular hypertension.

Zore M, Harris A, Tobe LA, et al. Generic medications in ophthalmology. The British Journal of Ophthalmology. Digiuni M, Manni G, Vetrugno M, et al. An evaluation of therapeutic noninferiority of 0. Angmo D, Wadhwani M, Velpandian T, Kotnal A, Sihota R, Dada T. Evaluation of physical properties and dose equivalency of generic pissing in bed branded latanoprost formulations.

Golan S, Rosenfeld E, Shemesh G, Kurtz S. Original and generic latanoprost for the treatment of glaucoma and ocular hypertension: are they really the same. A randomized, crossover, open label pilot study to evaluate the efficacy and safety of Xalatan in comparison with generic Latanoprost (Latoprost) in subjects with primary open angle glaucoma or ocular hypertension.

Indian Journal of Ophthalmology. Diagourtas A, Kagelaris K, Oikonomakis K, Droulias A, Kokolakis N, Papaconstantinou D. Prospective study comparing Xalatan((R)) eye drops and two similar generics as to the efficacy and safety profile.

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Comments:

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15.11.2020 in 21:21 Tern:
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16.11.2020 in 05:21 Maulkis:
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