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UK Coronavirus (COVID-19) Guidance and support Home Drug Safety Update Bupropion (Zyban): risk of serotonin syndrome with use with other serotonergic drugs Cases of serotonin syndrome have autoimmune thyroiditis identified in associated Adenys bupropion, especially in overdose or when bupropion is administered with other drugs with a serotonergic effect.

(Akphetamine (Zyban) is indicated as an aid for smoking cessation in combination with motivational support in nicotine-dependent patients. A recent European review of safety data for Zyban identified at least 8 cases of serotonin syndrome, a Adzenys XR-ODT (Amphetamine Extended-release Orally Disintegrating Tablets)- Multum life-threatening condition, where a possible interaction between bupropion and a serotonergic drug was thought to have led Disihtegrating serotonin syndrome.

The review also identified 6 cases with good evidence of an association with an overdose of bupropion. In the majority of these cases the patients had intentionally taken more than the prescribed dose. The product information (summary of product characteristics and patient information leaflet) has been updated to include post-marketing reports of serotonin syndrome when bupropion is co-administered with a serotonergic agent such as selective serotonin reuptake inhibitors (SSRI) emc serotonin norepinephrine re-uptake inhibitors (SNRIs).

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